铜的合成,表征,抗尼马杀菌和计算研究 (II) 复合物来源于用替代的希夫基联体
Salisu Y Lawan1, Naomi P Ndahi1, Ibrahim B Galadima2
1Department of Pure and Applied Chemistry, University of Maiduguri, Maiduguri, Nigeria.
Chemistry & biodiversity
|January 24, 2025
概括
一种新的替代的希夫基联结体及其铜 (II) 复合物被合成并测试了其杀性活性. 与铜复合物和卡博相比,这种连接物在抑制卵子化和导致死亡方面表现出更高的疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
- 计算化学计算化学
背景情况:
- 希夫基和它们的金属复合物以各种生物活动而闻名.
- 杀虫剂对于控制农业中的植物寄生性线虫至关重要.
- 化有机化合物经常表现出增强的生物特性.
研究的目的:
- 合成和表征一种新的替代的希夫基联结体 (HL) 和其铜 (II) 复合体 (CuL2).
- 评估HL和CuL2对植物寄生性线虫的体外杀菌活性.
- 为了比较HL和CuL2的疗效与商用杀虫剂卡博的疗效.
主要方法:
- 结合剂合成的凝结反应,随后与铜 (II) 乙酸盐复合.
- 使用NMR,UV-Vis,FTIR,TGA,元素分析,质谱和单晶X射线衍射进行表征.
- 在实验室内进行包括蛋化抑制和在24-72小时内在不同度 (50和100微米) 下确定死亡率的纳米杀菌试验.
- 密度函数理论 (DFT) 计算用于研究电子属性.
主要成果:
- 替代的希夫基联体 (HL) 和其铜 (II) 复合体 (CuL2) 已成功合成和表征.
- 与CuL2复合物和50μM的卡博 (Crf) 相比,联体HL表现出优异的杀虫活性,显示100%的蛋抑制和100%的死亡率.
- 在100μM时,HL和CuL2都实现了100%的蛋化抑制和100%的死亡率,表现优于carbofuran.
- DFT研究支持了关于化合物的电子性质的实验发现.
结论:
- 合成的替代的希夫基联体 (HL) 具有显著的杀菌性质,在较低度下优于其铜 (II) 复合物 (CuL2) 和商业杀菌剂碳水化合物.
- 连接体HL代表了开发新的,有效的杀虫剂的有希望的候选人.
- 对HL的作用机制和现场应用的进一步研究是有必要的.
更多相关视频
08:11Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria
Published on: May 16, 2025
51
11:04Ion Mobility-Mass Spectrometry Techniques for Determining the Structure and Mechanisms of Metal Ion Recognition and Redox Activity of Metal Binding Oligopeptides
Published on: September 7, 2019
9.1K
相关概念视频
03:02Colors and Magnetism
11.5K
Color in Coordination Complexes
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
When atoms or molecules absorb light at the proper frequency, their electrons are excited to higher-energy orbitals. For many main group atoms and molecules, the absorbed photons are in the ultraviolet range of the electromagnetic spectrum, which cannot be detected by the human eye. For coordination compounds, the energy difference between the d orbitals often allows photons in the visible range to be absorbed and emitted, which is seen as colors by the human...
11.5K
02:51Metal-Ligand Bonds
20.5K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
20.5K
02:54Coordination Compounds and Nomenclature
21.1K
In most main group element compounds, the valence electrons of the isolated atoms combine to form chemical bonds that satisfy the octet rule. For instance, the four valence electrons of carbon overlap with electrons from four hydrogen atoms to form CH4. The one valence electron leaves sodium and adds to the seven valence electrons of chlorine to form the ionic formula unit NaCl (Figure 1a). Transition metals do not normally bond in this fashion. They primarily form coordinate covalent bonds, a...
21.1K
00:56Extraction: Advanced Methods
405
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
405
01:20Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
1.8K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
1.8K
02:58Crystal Field Theory - Octahedral Complexes
26.1K
Crystal Field Theory
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
To explain the observed behavior of transition metal complexes (such as colors), a model involving electrostatic interactions between the electrons from the ligands and the electrons in the unhybridized d orbitals of the central metal atom has been developed. This electrostatic model is crystal field theory (CFT). It helps to understand, interpret, and predict the colors, magnetic behavior, and some structures of coordination compounds of transition metals.
CFT focuses on...
26.1K