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多双诱导细胞系和干细胞的毒性:一项审查

Muhammad Zaffar Hashmi¹, Anaela Shoukat², Siwatt Pongpiachan³

¹Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan. muhammadzaffar.hashmi@fulbrightmail.org.

Environmental geochemistry and health

|January 24, 2025

概括

电子垃圾中的多二 (PCB) 危害人类健康和生态系统. 本综述详细介绍了PCB毒性机制,重点关注细胞和干细胞的影响,指导环境政策.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
细胞生物学细胞生物学

背景情况:

多双 (PCB) 是电子废物 (电子废物) 中释放的持久性有机污染物.
环境中PCB污染对人类健康和生态系统构成重大风险.
了解PCB毒性对于环境保护和公共卫生至关重要.

研究的目的:

审查PCB对细胞增殖,细胞亡和细胞和干细胞中毒性的影响.
阐明PCB诱导的细胞损伤背后的分子机制.
为了区分各种类型的PCB的毒理影响 (化水平,类似于二氧化物和非类似于二氧化物).

主要方法:

关于PCB毒性研究的综合文献综述.
对细胞和干细胞对PCB的反应数据的分析.
检查参与PCB诱导毒性的分子途径.

主要成果:

高和二氧化类PCB在较高度下表现出更大的毒性.
PCB 诱导显著的肝毒性,致癌性,生殖性毒性,神经毒性和肺细胞毒性.
PCBs触发活性氧物种 (ROS),激活信号通路 (MAPK,NF-κB,细胞染色体),影响细胞增殖和细胞亡.

结论:

PCB,特别是高化和类似于二氧化的同源物,对细胞和干细胞群体构成重大毒理风险.
分子机制涉及ROS生成和随后关键细胞信号通路的激活.
调查结果为制定有关电子废物管理和PCB污染控制的明智政策提供了基础.

关键词:

亚洛克是一种.内分泌干扰物干扰内分泌干扰物聚化双烯的多种类型干细胞是一种干细胞.有毒性有毒性

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