日本性结肠炎的治疗模式和经济负担:回顾性索赔分析
Shingo Kato1, Bruno Casaes Teixeira2, Thomas Laurent3
1Saitama Medical Center, Saitama Medical University, Saitama, Japan.
Advances in therapy
|January 24, 2025
概括
日本性结肠炎 (UC) 治疗显示高成本和低于最佳的常规疗法使用. 需要改进治疗选择,以减少医疗保健资源的利用率和UC患者的经济负担.
科学领域:
- 胃肠病学 胃肠病学
- 卫生经济学 卫生经济学
- 现实世界的证据.
背景情况:
- 性结肠炎 (UC) 在日本是一个重大的经济负担.
- 了解当代UC治疗模式对于优化患者护理和资源配置至关重要.
研究的目的:
- 分析日本当前的性结肠炎 (UC) 治疗策略.
- 调查UC的经济影响,包括医疗保健资源利用率 (HCRU) 和成本.
- 评估现实世界常规治疗与临床指导方针的一致性.
主要方法:
- 对日本匿名索赔数据 (2018年6月至2022年12月) 的回顾性分析.
- 纳入标准:确认UC诊断,全身治疗要求和持续招生.
- 排除标准:年龄小于18岁,先前接受了全身性UC治疗,患有克罗恩/贝赫塞特病或先前进行了胆管切除术.
- 结果:治疗模式,HCRU和每人每月 (PPPM) 的UC相关成本.
- 通过长时间使用皮质类固醇 (>90天) 或皮质类固醇循环来定义的非最佳常规疗法.
主要成果:
- 包括15,429名患者;最常见的第一线治疗方法是5-氨基酸单疗法 (75.0%).
- 在39.7%的患者中,发生了治疗修改.
- 年均门诊次数:9.8;住院次数:23.9%.
- 平均PPPM总成本:76374.4日元.
- 在接受皮质类固醇治疗的患者中,39.8%的患者接受了低于最佳的治疗.
- 低于最佳的治疗与更高的HCRU和成本相关.
结论:
- 日本UC患者经历了相当大的成本和低于最佳的常规治疗.
- 需要制定UC治疗策略,尽量降低成本和HCRU.
- 优化传统疗法和探索替代疗法可以改善患者的治疗结果,并减少UC的经济负担.
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