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Updated: May 31, 2025

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
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机器学习驱动的发现结构相关的自然产品作为心脏热SERCA2a的激活剂

Carlos Cruz-Cortés1, Eli Fernández-de Gortari2,3, Rodrigo Aguayo-Ortiz4

  • 1Center for Arrhythmia Research, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI-48109, USA.

ChemMedChem
|January 24, 2025
PubMed
概括

研究人员确定了激活心脏质网膜Ca2+-ATPase (SERCA2a) 的天然产品,这是心力衰竭治疗的关键标. 两种化合物,雅库金A和Alpinoid D,在细胞和计算模型中显示出显著的潜力.

关键词:
这就是 SERCA2a.心脏气的心脏气.心脏衰竭是因为心脏衰竭.机器学习是机器学习.小分子激活器激活器小分子查小分子查

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