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将废物转化为宝藏:功能化生物质衍生碳点用于超选择性可视化和根除格拉姆阳性细菌

Ke-Fei Xu¹, Zihao Wang¹, Macheng Cui¹

¹State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, 2 Southeast University Road, Nanjing, 211189, P. R. China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 24, 2025

概括

研究人员开发了新的生物质碳点 (BCDs),用于精确检测和消灭格兰正细菌. 这些药物向细菌酸甘,增强光动力疗法,对伤口愈合应用有希望.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
微生物学微生物学

背景情况:

阳性细菌对健康构成重大风险,但目前的检测和根除方法缺乏特异性.
制定有针对性的策略对于有效治疗和控制格拉姆阳性细菌感染至关重要.

研究的目的:

合成和表征生物质碳点 (BCDs) 以精确准和消灭阳性细菌.
开发一种用于同时成像和治疗格拉姆阳性细菌感染的治疗药物.
探索BCD在光动力疗法 (PDT) 和伤口愈合应用中的潜力.

主要方法:

生物质碳点 (BCD) 由紫米液体与小麦胚芽聚胺类残留物合成.
光素异硫酸 (FITC) 与BCD (CDF) 结合,用于选择性Gram阳性细菌染色.
抗菌光动力学疗法 (PDT) 用于抗菌光动力学疗法 (CDPs) 与BCD结合使用Protoporphyrin (PpIX).
进行了体外和体内研究,以评估CDF和CDP的疗效.

主要成果:

CDF可以选择性地和快速地染色格拉姆阳性细菌,准丁糖,即使在混合细胞群中也具有超选择性可视化.
CDPs诱导细菌聚合并产生单片氧,从而通过PDT消除生物膜.
在受感染的小鼠中,CDP介导的PDT调节了抗炎反应,并促进了伤口愈合.

结论:

可再生生物质资源可以被利用来创造有效的向格拉姆阳性细菌的毒剂.
开发的CDF和CDP为先进的细菌检测和治疗提供了一个有前途的平台.
这种方法有可能在未来的临床应用中用于管理格拉姆阳性细菌感染和相关并发症.

关键词:

抗菌疗法是一种抗菌疗法.细菌成像检测细菌成像检测生物质碳点生物质碳点细胞壁准探针的探针.伤口愈合伤口愈合

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