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不同治疗对多发性硬化症患者视网膜厚度变化的影响:一篇综述

Armin Adibi^1,2, Iman Adibi^1,2, Milad Javidan^1,2

¹Department of Neurology, Isfahan University of Medical Sciences, Isfahan, Iran.

CNS neuroscience & therapeutics

|January 24, 2025

概括

不同的多发性硬化症 (MS) 治疗方法对视网膜厚度的影响不同. 单克隆抗体表现出最强的神经保护作用,保护视网膜层,而注射药物影响较小.

科学领域:

神经免疫学神经免疫学
眼科医生眼科眼科
神经学神经学

背景情况:

多发性硬化症 (MS) 是一种具有多种临床表现的中枢神经系统自身免疫性疾病.
视网膜变薄,可通过光学连贯性断层扫描 (OCT) 检测,作为MS神经退行症的生物标志物,即使没有视神经炎.
在MS中神经退行扩展到最初的病变之外,影响疾病的整体进展.

研究的目的:

审查各种多发性硬化症 (MS) 治疗对视网膜厚度的影响,通过光学连贯性断层扫描 (OCT) 测量.
为了比较不同MS治疗类别在视网膜层上的神经保护作用.

主要方法:

在患有多发性硬化症 (MS) 的患者中,使用光学连贯性断层扫描 (OCT) 评估视网膜层厚度的研究的系统综述.
分析数据,比较可注射疗法,口服药物和单克隆抗体对视网膜缩的影响.
评估特定的OCT参数,如质细胞内状层和视网膜神经纤维层厚度.

主要成果:

可注射疗法 (干扰素β,格拉提拉乙酸) 对视网膜缩表现出适度的影响.
口服药物 (Fingolimod,Teriflunomide,Dimethyl fumarate) 有多种影响;Fingolimod可能会保护,但可能会导致斑点.
单克隆抗体 (Alemtuzumab,Rituximab,Ocrelizumab,Natalizumab) 显示出显著的神经保护作用,Natalizumab在减少视网膜缩方面最有效.

结论:

治疗多发性硬化症的有效性因亚型和个体因素而异.
单克隆抗体提供了相当大的神经保护,保护了视网膜层.
需要对长期影响和与MS整体进展和残疾的相关性进行进一步的研究.

关键词:

药物治疗是药物治疗.多发性硬化症多发性硬化症光学连贯性断层扫描技术视网膜视网膜视网膜是一个

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