异常的食道扫描与系统性硬化症患者的明显临床表型有关
Antonio D Salas1, Lisa R Yanek1, Laura K Hummers1
1Johns Hopkins University, Baltimore, Maryland.
ACR open rheumatology
|January 24, 2025
概括
在全身性硬化症 (SSc) 患者的透视镜中,食道过渡缓慢表明严重的疾病表型,类似于缺席的缩水力. 这表明光束扫描可以帮助识别SSc患有并发症风险的患者.
科学领域:
- 胃肠病学 胃肠病学
- 类风湿病学 类风湿病学
- 核医学就是核医学.
背景情况:
- 系统性硬化症 (SSc) 是一种结缔组织疾病,其特征是纤维化和血管异常.
- 缺席的收缩性 (AC) 在食道尺度上与严重的SSc表型有关.
- 食道光学提供了一种非侵入性的方法来评估食道功能.
研究的目的:
- 为了调查缓慢的食道过渡是否与SSc患者的严重临床表型相关.
- 评估光束图像作为SSc.风险分层的潜在工具.
主要方法:
- 一组131名SSc患者接受了食道扫描.
- 收集了临床,人口和血清学数据.
- 评估了胃肠道症状 (GIT 2.0),SSc严重程度 (Medsger分数) 和dysautonomia (COMPASS 31).这些症状包括:
主要成果:
- 60%的患者表现出延迟的食道过渡.
- 延迟过境与扩散的SSc,严重的肺部参与和严重的雷诺现象有关.
- 肺部对一氧化碳的扩散能力较低,与食道传输时间较长相关.
结论:
- 迟延的食道过渡在光学扫描上识别SSc患者具有更严重的表型,可比作AC在测量力.
- 食道扫描可能有助于识别易患胃肠道和肠外并发症的SSc患者.
相关概念视频
Barrett Esophagus-II: Clinical Manifestations and Management
103
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
103
Esophageal Strictures-II: Clinical Features and Management
45
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
45
Esophageal Strictures-I: Introduction
64
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
64
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
48
This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
48
Gastroesophageal Reflux Disease II: Clinical Features and Management
54
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
54
Barrett Esophagus-I: Introduction
64
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
64


