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Updated: May 31, 2025

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
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From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia

Published on: October 19, 2014

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针对血液恶性瘤中的蛋白质-蛋白质相互作用

Tomasz Cierpicki1, Jolanta Grembecka1

  • 1Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA; email: tomaszc@umich.edu, jolantag@umich.edu.

Annual review of pathology
|January 24, 2025
PubMed
概括

针对蛋白质与蛋白质相互作用 (PPI) 的小分子抑制剂在治疗血液癌症方面显著有前途. 最近的临床成功,包括FDA批准的venetoclax,强调了阻止这些关键的癌症驱动相互作用的治疗潜力.

关键词:
发现药物的发现.血液学恶性瘤 血液学恶性瘤蛋白质蛋白质相互作用有针对性的治疗方法.

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