BuffExDb:基于网络的组织特异性基因表达资源,用于Bubalus bubalis中的育种和保护计划
Naina Kumari1,2, Samir Kumar3, Anupama Roy1
1Division of Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, Library Avenue, PUSA, New Delhi 110012, India.
Database : the journal of biological databases and curation
|January 24, 2025
概括
研究人员创建了BuffExDb,这是一个新的水牛基因表达数据库. 该资源有助于了解组织特异性基因,以改善水牛繁殖和保护工作.
科学领域:
- 动物基因组学 动物基因组学
- 生物信息学是一种生物信息学.
- 畜牧科学 畜牧科学 畜牧科学
背景情况:
- 畜牧业对全球可持续发展和减少贫困至关重要.
- 在亚洲,水牛在经济上至关重要,在牛奶生产方面超过了牛.
- 对于水牛来说,有限的基因组资源阻碍了特征增强,以增加产量.
研究的目的:
- 为了解决水牛基因组和转录基因组数据的稀缺问题.
- 开发一个全面的,用户友好的水牛基因表达数据库.
- 促进加强水牛繁殖和保护的研究.
主要方法:
- 从23个BioProjects中的438个生物样本中分析了2429个转录组.
- 利用生物信息学工具处理来自76种组织和细胞类型的数据.
- 开发了一个关系水牛表达式数据库 (BuffExDb),具有三层架构.
主要成果:
- 现在可以使用BuffExDb数据库 (http://46.202.167.198/buffex/).
- 该数据库允许轻松检索和功能注释组织特异性基因 (TSG).
- 使用Tau分数参数识别了TSG,并通过基因本体学丰富分析了它们的作用.
结论:
- BuffExDb是第一个可导航和可过的水牛基因表达数据库.
- 提供了生物,功能和进化研究的基本数据.
- 支持未来的基因组研究,协会研究和水牛繁殖计划.
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