在轻度血管认知障碍患者中进行的跨骨多普勒超声波随访研究
Mariagiovanna Cantone1, Manuela Pennisi2, Giuseppe Lanza3,4
1Neurology Unit, Policlinico University Hospital "G. Rodolico-San Marco", Catania, Italy.
PloS one
|January 24, 2025
概括
跨骨多普勒声谱 (TCD) 可以帮助监测患有痴呆症风险的患者血管认知障碍 (VCI) 的进展. 纵向TCD测量与认知衰退相关,有助于早期发现和管理.
科学领域:
- 神经学 神经学
- 血管医学 血管医学
- 神经声学是一种神经声学.
背景情况:
- 对于患有痴呆风险的轻度血管认知障碍 (VCI) 患者的跨皮多普勒声学 (TCD) 有有限的数据.
- 之前的研究表明,小血管疾病的VCI患者中大脑低和血管阻力升高.
- 需要纵向数据来了解疾病的进展,并识别可预测的TCD标志物.
研究的目的:
- 进行VCI患者的临床,精神病理和神经声学随访.
- 为了随着时间的推移监测疾病的进展.
- 确定能够检测VCI进展的TCD措施.
主要方法:
- 127名VCI患者 (平均年龄73.6岁) 在大约5年后被重新评估.
- 认知功能 (MoCA),抑郁症状 (HDRS) 和执行功能 (StroopT) 被评估.
- 测量了跨骨多普勒 (TCD) 参数,包括平均血液流速 (MBFV),PSV,EDV,PI和RI.
主要成果:
- 患者的MoCA和StroopT得分显著恶化,抑郁症状持续.
- 观察到TCD参数的显著变化,包括增加PSV和PI,减少EDV.
- 在TCD指数 (MBFV,RI) 和认知变化 (MoCA,StroopT) 的变化之间发现了相关性.
结论:
- 跨骨多普勒声谱 (TCD) 显示了早期检测,监测和管理风险患痴呆症的VCI患者的潜力.
- 探索早期TCD标志物可以识别患有更高进展风险的患者.
- 与对照组和神经成像进行进一步的研究是有必要的.
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