与蒙古多发性硬化症患者的维生素D水平相关的因素
Myadagmaa Jaalkhorol1,2, Amarsaikhan Dashtseren2,3, Gantuya Magnaibayar2,4
1Department of Health Research, Graduate School, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia.
PloS one
|January 24, 2025
概括
在蒙古多发性硬化症 (MS) 患者中,维生素D缺乏是常见的,尽管与对照组相比,在统计学上并不显著. 较低的维生素D水平与冬季和儿童母乳养有关.
科学领域:
- 神经学 神经学
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 受遗传和环境因素的影响,包括维生素D.
- 较高的度,比如蒙古 (45°N),与由于太阳光有限而导致维生素D缺乏的风险增加有关.
- 维生素D缺乏是MS的潜在环境风险因素.
研究的目的:
- 为了在蒙古的MS患者和对照人群之间比较维生素D水平.
- 在这个人群中确定与低维生素D水平相关的因素.
主要方法:
- 横截面研究比较31名MS患者和31名蒙古人对照.
- 使用线性混合效应回归分析来评估关联.
- 变量包括病例状况,社会人口统计和预定义因素.
主要成果:
- 与对照人群相比,MS患者在夏季和冬季的维生素D水平中位数较低.
- 在MS患者中观察到维生素D的季节性下降较小.
- 在MS患者中,维生素D缺乏更为普遍,尽管在统计学上并不显著. 冬季季节和儿童母乳养与维生素D水平较低有关.
结论:
- 在蒙古的MS患者中,维生素D缺乏是普遍存在的.
- 行为因素可能会影响MS患者的维生素D水平.
- 研究结果表明,需要针对性建议,以保持MS患者维生素D水平的适当水平.
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