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Updated: May 31, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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SPT5通过库林3-ARMC5识别调节RNA聚合酶II的稳定性

Yuki Aoi1, Leila Iravani1, Isabella C Mroczek1

  • 1Simpson Querrey Institute for Epigenetics, Department of Biochemistry and Molecular Genetics Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Science advances
|January 24, 2025
PubMed
概括

SPT5的损失会使基因促进体的RNA聚合酶II (Pol II) 不稳定. 由CDK9调节的CUL3-ARMC5复合体针对这个有缺陷的Pol II通过非正规终结路径进行降解.

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