人类原始B细胞识别了大流行前的流感病毒血素
Jared Feldman1, Ana Sofia Ferreira Ramos2, Mya Vu1
1Ragon Institute of Mass General, MIT, and Harvard, Cambridge, MA 02139, USA.
Science immunology
|January 24, 2025
概括
研究人员描述了人类原始B细胞对禽流感病毒血素的反应. 这项研究揭示了可以识别高度致病性禽流感 (HPAI) H5 的B细胞的剧目,有助于预测免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 结构生物学 结构生物学
背景情况:
- 了解原始B细胞谱系对于预测对新型病原体的反应至关重要,例如高度致病性禽流感 (HPAI) H5Nx病毒.
- 原始的B细胞对新出现的,大流行前病毒的反应能力在很大程度上仍未确定,这对疫情准备构成了挑战.
研究的目的:
- 分析原始B细胞对原型HPAI H5菌株的血凝素 (HA) 蛋白的反应性.
- 描述B细胞识别HPAI H5 HA的特异性和中和能力.
主要方法:
- 对人类原始B细胞对HPAI H5血素的反应性进行分析.
- 单克隆抗体 (mAbs) 的隔离和分类基于参与的HA表位.
- 确定一个mAb-H5 HA复合体的冷电子显微镜结构.
主要成果:
- 与针对季节性H1N1菌株的交叉反应性B细胞相比,针对HA头域的H5特异性人类原始B细胞的频率更高.
- 隔离的单克隆抗体直接从生殖线中中和H5N1病毒.
- 结构分析定义了被中和单克隆抗体识别的表位.
结论:
- 这项研究定义了能够识别潜在的动物传染性HPAI的原始人类B细胞谱.
- 这些发现为早期B细胞对禽流感的反应提供了洞察力,这对于疫苗开发和流行病准备至关重要.
更多相关视频
04:47A Method to Assess Fc-mediated Effector Functions Induced by Influenza Hemagglutinin Specific Antibodies
Published on: February 23, 2018
7.7K
13:12Quantitative Analyses of all Influenza Type A Viral Hemagglutinins and Neuraminidases using Universal Antibodies in Simple Slot Blot Assays
Published on: April 4, 2011
18.2K
相关概念视频
Immune Response Against Viral Pathogens
735
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
735
Cross-reactivity
30.9K
Overview
30.9K
Humoral Immune Responses
71.3K
Overview
71.3K
