腰腹部直径的增加与结石的风险更高有关
Wei Song1, Shugen Li2, Guangchun Wang1
1Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
PloS one
|January 24, 2025
概括
增加的腹部肥胖,以斜腰腹部直径 (SAD) 衡量,是结石疾病 (KSD) 的重要危险因素. 颗粒细胞计数调解了这种关联,表明了早期风险评估的潜力.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 代谢健康 代谢健康
- 肥胖问题研究研究
背景情况:
- 研究了腹部肥胖的标志物 - - 斜腰腹直径 (SAD) 与美国人口中的结石疾病 (KSD) 之间的联系.
- 探索潜在的生物机制,并评估KSD风险的预测模型.
研究的目的:
- 确定SAD是否是KSD的独立风险因素.
- 确定SAD-KSD关系中的调解因素.
- 评估KSD的预测模型的临床实用性.
主要方法:
- 利用了11,671名参与者的数据 (1,136名KSD).
- 使用后勤回归,剂量反应曲线和调解分析.
- 开发并验证了使用ROC和校准曲线的预测模型;分析了血液学指标.
主要成果:
- SAD表现出与KSD的强烈,积极的关联,独立于混因子.
- 预测模型显示中等准确性 (AUC=0.661) 和临床效用.
- 颗粒细胞计数 (GRAN) 显著调解了SAD-KSD关系 (P < 0.001).
结论:
- 斜腰腹部直径是结石疾病的重要危险因素.
- 腹部肥胖在结石形成中起着至关重要的作用.
- 开发的预测模型显示了早期KSD风险评估和管理的前景.
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