辅助辐射改善了上皮癌的生存结果:基于人口的研究
Kunming Zhan1,2, Xianguo Ruan1, Hongtao Jia2
1Department of Urology, Xiang Yang No.1 People's Hospital Affiliated Hospital of Hubei University of Medicine, Xiangyang, China.
Medicine
|January 24, 2025
概括
辅助放射治疗 (RT) 显著改善了上腺皮质癌 (ACC) 患者的生存结果. 这项研究开发了一种预测存活率的诺米克图,建议对ACC进行常规RT应用.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 手术瘤学手术瘤学
背景情况:
- 皮上腺癌 (ACC) 是一种罕见且具有攻击性的内分泌恶性瘤.
- 对ACC的最佳辅助治疗策略仍在研究中.
- 辅助放射治疗 (RT) 是一种潜在的方法,可以改善切除ACC的结果.
研究的目的:
- 评估辅助RT在上皮癌 (ACC) 患者的临床益处和生存结果.
- 确定影响ACC生存的独立风险因素.
- 开发和验证ACC患者的整体存活率 (OS) 和癌症特异性存活率 (CSS) 的预测性名谱.
主要方法:
- 从监测,流行病学和最终结果 (SEER) 数据库 (2010-2015) 中对426名ACC患者的回顾性分析.
- 前进一步的考克斯比例危险回归以确定预后因素.
- 使用一致性指数,ROC曲线,校准曲线和决策曲线分析开发和验证名ogram.
主要成果:
- 辅助RT给了19.7%的患者.
- 六个因素 (年龄,T阶段,手术类型,辐射,骨/肝转移) 显著影响了OS.
- 五个因素 (T阶段,手术类型,辐射,骨/肝转移) 显著影响了CSS.
- 开发的诺米图表显示出令人满意的区分能力 (C指数:OS 0.756,CSS 0.749) 和良好的预测准确性.
结论:
- 辅助放射治疗 (RT) 与上皮癌 (ACC) 患者的整体和癌症特异性生存率的显著改善有关.
- 开发的名图为预测生存概率提供了一个可靠的工具.
- 常规应用辅助RT推给患有上腺皮质癌的患者.
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