相关实验视频
Updated: May 31, 2025

Blood Flow Imaging with Ultrafast Doppler
Published on: October 14, 2020
用双流速自动采样动脉血液的外部延迟和分散校正
Benjamin Brender1,2, Lubna Burki3, Josefina Jeon1
1Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
一种新的校正方法准确地调整自动取血系统 (ABSS) 的数据,以适应PET成像期间流量变化. 这通过纠正延迟和分散来改善放射追踪器测量,这对于精确的动脉输入功能的量化至关重要.
科学领域:
- 核医学是一种核医学.
- 放射性药物化学 放射性药物化学
- 生物医学工程 生物医学工程
背景情况:
- 用于PET成像的动脉采样需要使用自动血液采样系统 (ABSS) 精确测量放射追踪器度.
- 数据采集期间血液流速的变化可能会导致ABSS测量中的误差,原因是延迟和分散.
- 精确的动脉输入功能 (AIF) 对于定量PET成像至关重要.
研究的目的:
- 在流速发生变化时开发和验证用于ABSS数据采集的外部延迟和分散校正程序.
- 用于测量常见的PET射线追踪器 ([11C]CURB, [18F]FDG, [18F]FEPPA, [18F]SynVesT-1) 的外部分散常量.
- 通过使用曲线下面积 (AUC) 比率和修改的模型选择标准 (MSC) 来评估拟议的校正方法的有效性.
主要方法:
- 测量了各种流速 (350,300,180,150毫升/小时) 的外部延迟和分散常量,使用盐溶液中的18F-的矩形输入.
- 校正程序通过模拟流速变化 (350至150毫升/小时和300至180毫升/小时) 来验证.
- 常量被建模为在流量之间线性过渡,并使用AUC比率和MSC评估修正曲线.
主要成果:
- 拟议的校正方法成功地纠正了ABSS输出在流量变化期间的外部延迟和分散.
- 经过校正后,AUC比率从~10% (未经校正) 降低到<1%,表明准确度有所提高.
- 修改后的模型选择标准 (MSC) 显示大约增加了5倍,这意味着更好的模型适合.
结论:
- 开发的外部延迟和分散校正程序对于在流速变化期间获得的ABSS数据是有效的.
- 这种方法提高了PET成像中动脉输入功能的量化准确度.
- 该研究还首次使用血液模拟器测量了外部延迟和分散常数,为血液提供了切实可行的替代方案.
更多相关视频
07:20A Novel Approach to Overcome Movement Artifact When Using a Laser Speckle Contrast Imaging System for Alternating Speeds of Blood Microcirculation
Published on: August 30, 2017
11:04Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
Published on: September 1, 2014
相关概念视频
Assessment of blood pressure in brachial artery(two-step method)
Equipments Used To Measure Blood Pressure
This invasive approach involves cannulating a peripheral artery. During each cardiac contraction, pressure generates mechanical motion within the catheter, transmitted through rigid, fluid-filled tubing to a transducer. This transducer converts mechanical motion into electrical signals displayed as waveforms on a monitor. An automatic flushing system prevents blood backflow. Due to the potential risk of unexpected arterial blood loss, this method is primarily used in intensive...
Assessing Blood pressure using a doppler ultrasound
Pre-Procedural Guidelines for Doppler Ultrasound Blood Pressure Assessment:
Preparation of Equipment:
Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.