同步双边/反侧桃体癌的患病率:系统性审查和元分析
Alex Charlton1, Zahir Mughal2, Florida Sharin3
1University Hospitals of Derby and Burton NHS Foundation Trust, UK.
Oral oncology
|January 24, 2025
概括
同步 contralateral 桃体癌 (SCTC) 影响4%的患者,在未知初级的头部和部状细胞癌 (HNSCCUP) 中增加到10%. 反侧桃体切除术通常是必要的,特别是在HNSCCUP病例中.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 头部和部手术 头部和部手术
- 在瘤学瘤学.
背景情况:
- 未知初级的头部和部状细胞癌 (HNSCCUP) 存在诊断方面的挑战.
- 同步 contralateral 桃体癌 (SCTC) 是桃体恶性瘤的一个潜在并发症.
研究的目的:
- 为了确定患有桃体癌或HNSCCUP的患者中SCTC的患病率.
- 评估影响SCTC流行的因素,包括HPV/p16状态.
主要方法:
- 系统审查和对13项回顾性研究的元分析.
- 包括2623名被诊断患有桃体癌或HNSCCUP的患者.
主要成果:
- 总体上,SCTC的综合流行率为4%,在HNSCCUP病例中增加到10%.
- 与HPV/p16阳性瘤 (3%) 相比,HPV/p16阴性瘤的SCTC患病率 (8%) 更高.
- 在临床或成像评估中,SCTC的手术前检测经常被遗漏.
结论:
- 在HNSCCUP和桃体恶性瘤中,SCTC是一个重要的关注点,需要对逆侧桃体切除术进行知情讨论.
- 一般建议对HNSCCUP进行逆侧桃体切除术,根据患者和瘤特征进行量身定制的方法.
- 需要进一步的前性研究来阐明神秘SCTC的临床意义,并优化管理策略.
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