在患有ADHD的儿童和青少年的发展过程中表观遗传年龄
Jo Wrigglesworth1, Peter D Fransquet1, Peter Ryabinin2
1Centre for Social and Early Emotional Development and School of Psychology, Deakin University, Burwood, Victoria, Australia; Biological Neuropsychiatry & Dementia Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Psychiatry research
|January 24, 2025
概括
这项研究发现,有或没有注意力缺陷/多动症障碍 (ADHD) 的儿童之间的表观遗传衰老率没有显著差异. 通过DNA甲基化年龄来衡量的生物衰老,在这个儿科队列中的组之间没有差异.
科学领域:
- 神经发育障碍 神经发育障碍
- 表观遗传学和衰老问题
- 儿科卫生健康 儿科卫生健康
背景情况:
- 注意缺陷/多动障碍 (ADHD) 是一种常见的神经发育状况,症状呈现变化.
- 通过DNA甲基化年龄 (EpiAge) 评估的生物衰老,可以提供对发育轨迹的见解.
- 研究ADHD的表观遗传衰老可能会揭示潜在的生物机制.
研究的目的:
- 检查患有ADHD和没有ADHD的儿童间表观遗传衰老 (EpiAge Gap) 的差异.
- 在儿科队列中分析EpiAge Gap的横截面和纵向变化.
- 为了确定表观遗传衰老轨迹是否在患有多动症的发展个体中存在差异.
主要方法:
- 利用三个表观遗传钟 (PedBE,Horvath,皮肤和血液) 来估计EpiAge.
- 分析了NICAP队列中169名参与者的唾液样本 (91名患有多动症).
- 包括横截面和纵向评估,在ADHD-1000队列中复制.
主要成果:
- 在横截面分析中,在所有时钟中,在ADHD和对照组之间没有观察到EpiAge Gap的显著差异.
- 纵向分析还显示,与对照人群相比,ADHD患者的EpiAge Gap与时间相比没有显著变化.
- 在初级 (NICAP) 和复制 (ADHD-1000) 队列中,研究结果一致.
结论:
- 该研究没有发现有或没有ADHD的儿童和青少年表观遗传衰老差异的有力证据.
- 需要进行更大,更长时间的队列研究,以进一步探索跨发育阶段的ADHD的生物年龄.
- 未来的研究应该考虑长时间的观察期,以捕捉表观遗传衰老和ADHD的发育细微差别.
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