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通过调整它们的曲折压力来控制单分散的脂涂层微泡的稳定性

Benjamin van Elburg¹, Anne Lassus², Samir Cherkaoui²

¹Physics of Fluids Group, TechMed Centre, University of Twente, P.O. Box 217, Enschede, 7500 AE, the Netherlands.

Journal of colloid and interface science

|January 24, 2025

概括

微泡外的曲压力对稳定性至关重要,随着PEGylated脂质含量降低而增加. 加热微气泡可以选择性地排出PEGylated脂质,显著提高它们在压力下的稳定性.

科学领域:

生物材料科学是生物材料的科学.
声学物理学的声学物理学
纳米技术纳米技术

背景情况:

单分散的脂涂层微气泡对于基于超声波的诊断和治疗至关重要.
在生理压力下微泡外的完整性对它们的功能至关重要.
的组成,特别是脂与PEGylated脂的比例,影响了微泡的稳定性.

研究的目的:

为了研究PEGylated脂质含量与微泡外屈曲压力之间的关系.
为了确定高温是否可以选择性地去除PEGylated脂质并改善微泡稳定性.
评估增强的曲折压力对微泡在生理条件下的性能的影响.

主要方法:

使用微流体流量聚焦制备了具有不同摩尔分量的PEGylated脂质 (DPPE-PEG5000和DSPC) 的微泡.
使用超声衰减光谱测量在不同环境压力下曲压力 (P_b).
微泡悬浮被加热以评估温度对P_b的影响,并通过HPLC分析PEG含量.

主要成果:

从10%降低PEG摩尔分数到1.5%,使曲压力从3kPa增加到27kPa.
在60°C以10mol%的PEG加热微气泡一个小时,由于选择性PEG化脂质排放,P_b增加了20kPa.
增强的曲压力提高了微气泡的稳定性,使它们能够承受高达45kPa的压力,超过体内静脉压.

结论:

微泡外的曲压力受到PEGylated脂质分数的直接影响.
控制热处理提供了一种方法,通过选择性去除PEGylated脂质来增强微泡的稳定性.
改进的微气泡稳定性对基于超声波的先进医疗应用有重大影响.

关键词:

热处理是一种热处理.接口的复原学接口的复原学微气泡是一种微气泡.一种单一分散的物质.这是一种PEGylated脂质.贝的曲是因为贝的曲稳定的稳定性稳定的稳定性

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