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Updated: May 31, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

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Published on: October 26, 2015

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开发1,2,3-triazole杂交物作为多面性抗癌剂,共同准EGFR/mTOR通路和蛋白脱聚合的发展

Mennatallah A Shaheen1, Khaled M Darwish2, Safaa M Kishk3

  • 1Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia 41522 Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University, Egypt.

Bioorganic chemistry
|January 24, 2025
PubMed
概括

新的1,2,3-triazole杂交物对黑色素瘤和结直肠癌细胞表现出强大的抗癌活性. 化合物4b和4e对正常细胞具有低毒性,并诱导细胞亡,细胞循环停止,并抑制蛋白聚合和EGFR活性.

关键词:
1,2,3-三醇是一种哈尔科内斯 (Chalcones) 是一种石头.结肠直肠癌是一种癌症.计算研究是计算研究.欧洲农业基金/mTOR图布的脱聚合方式

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Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics06:00

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