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Updated: May 31, 2025

Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection
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Spatial Profiling of Protein and RNA Expression in Tissue: An Approach to Fine-Tune Virtual Microdissection

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基于微流体学和转移学习的复杂组织的高分辨率空间分辨蛋白质学

Beiyu Hu1, Ruiqiao He2, Kun Pang2

  • 1Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Key Laboratory of Systems Biology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, China.

Cell
|January 24, 2025
PubMed
概括

一个名为PLATO的新框架 (平行流投影和跨OMIC数据的转移学习) 实现了高分辨率的空间蛋白质学. 这种方法可以映射整个组织中的数千种蛋白质,

关键词:
深度学习质谱学微流体空间多态学空间蛋白质组学断层扫描

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相关概念视频

Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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