相关实验视频
Updated: May 31, 2025

Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
非工业化饮食的心脏代谢益处与肠道微生物组调节有关
Fuyong Li1, Anissa M Armet2, Katri Korpela3
1Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB T6G 2E1, Canada; Department of Animal Science and Technology, College of Animal Sciences, Zhejiang University, Hangzhou 310058, Zhejiang, China.
恢复饮食,模仿非工业化的饮食模式,改善了成年人的肠道健康和心脏代谢指标. 这种饮食方法有望预防与肠道微生物组变化相关的慢性疾病.
科学领域:
- 微生物组研究
- 营养科学
- 预防慢性疾病
背景情况:
- 工业化对肠道微生物产生负面影响,增加慢性非传染性疾病的风险.
- 恢复祖先的微生物组状态可以抵消这些不良影响.
研究的目的:
- 评估使用"恢复饮食"和Limosilactobacillus reuteri的微生物组恢复策略.
- 评估对肠道微生物组合和宿主心脏代谢健康的影响.
主要方法:
- 一个随机控制的加拿大成年人养试验.
- 干预包括"恢复饮食"和/或Limosilactobacillus reuteri (PB-W1).
- 分析了肠道微生物组的变化,血代谢物和心脏代谢参数.
主要成果:
- "恢复饮食"增强了L. reuteri的持久性,并纠正了工业化引起的微生物组变化.
- 观察到与慢性疾病病因相关的微生物群衍生血代谢物的有益变化.
- 显著的心脏代谢益处独立于L. reuteri,由微生物组特征预测.
结论:
- 针对肠道微生物组的饮食干预可以改善宿主微生物组的相互作用.
- 这一战略有潜力指导饮食建议和开发慢性疾病的治疗营养方法.
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