一个MDR Salmonella Enteritidis亚系与中国的胃肠炎爆发和侵入性疾病有关
Xiaoyi Zheng1, Ying Xiang2, Xiaoying Li2
1Center for Disease Control and Prevention of Chinese PLA, Beijing, China; College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
The Journal of infection
|January 24, 2025
概括
耐多药沙门氏菌 (Salmonella Enteritidis) 在中国已经演变为独特的集群,导致广泛的胃肠炎和侵袭性非类型型型沙门氏菌病 (iNTS). 这些发现凸显了加强监测和基因组流行病学的迫切需要,以管理这种公共卫生威胁.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 流行病学 流行病学
背景情况:
- 沙门氏菌 (Salmonella enterica serovar Enteritidis) (S. Enteritidis) 是一个重要的全球性病原体,导致大量的疾病负担.
- 一种具有多药耐药性 (MDR) 的S.Enteritidis流行亚系已经出现,导致长期的胃肠炎爆发和中国的侵袭性非类型型沙门氏菌 (iNTS) 疾病.
研究的目的:
- 研究中国多药耐药S. Enteritidis亚系的种群结构,进化史和遗传特征.
- 了解这些流行病菌株抗菌素耐药性 (AMR) 和毒性的基因组基础.
主要方法:
- 全基因组测序和对来自中国的729个S. Enteritidis分离物进行抗菌耐药性 (AMR) 测试 (1994-2021).
- 遗传学分析以确定全球范围内的人口结构和进化关系.
- 分子研究AMR基因,毒性因子,移动遗传元素和泛基因组.
主要成果:
- 中国S.Enteritidis分离物显示MDR率高,在过去十年中 iNTS菌株显著增加.
- 遗传学分析显示,大多数分离物属于全球流行血统L1,形成L1.2和L1.3.3亚系中的两个主要中国分类 (MCC1&2).
- 这些类 possess 拥有众多AMR和毒性基因,主要归因于混合和共存的AMR等离子体.
结论:
- 独特的MDR S. Enteritidis克隆集群 (MCC1&2) 在中国演化,扩展了具有独特遗传特征的全球大流行血统L1.
- 这些类型在中国造成了广泛的胃肠炎爆发和严重的INTS病例,构成严重的公共卫生风险.
- 实施"一个健康"战略,日常监测和基因组流行病学研究对于全球监测和控制S. Enteritidis流行病至关重要.
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