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热挤出FDM3D打印的氧化聚乙烯片:溶解成像分析胀和药物释放的分析
Haja Muhamad1, Abdul Basit Bashir2, James Charlton-Harrison2
1Department of Pharmacy, University of Huddersfield, Huddersfield HD1 3DH UK.
制造了3D打印的PEO片,其度不同,甲醇化物度不同. 较高的药物负载增加了药片粗性和胀,但由于凝层的形成,药物释放率下降.
科学领域:
- 制药技术 制药技术 制药技术
- 材料科学 材料科学 材料科学
- 药物输送系统 药物输送系统
背景情况:
- 药物遗传学推动了对定制药物的需求.
- 融合沉积建模 (FDM) 3D打印为量身定制的药物输送提供了潜力.
- 聚乙烯氧化物 (PEO) 和聚乙烯甘醇 (PEG) 适用于3D打印的剂型.
研究的目的:
- 研究使用PEO和PEG 6K的3D打印口服剂型的制造和表征.
- 探索普拉诺洛尔化度对光纤可打印性,机械性质和表面特征的影响.
- 通过溶解成像来评估药物含量对胀,溶解和药物释放概况的影响.
主要方法:
- 热挤出用于使用不同度的propranolol化制造丝.
- 机械测试 (弹性应力) 和表面分析 (粗度,湿透性/接触角度) 的丝和片.
- 溶解成像可视化胀动态和药物释放从3D打印的PEO片.
主要成果:
- 增加propranolol化的度减少了丝的曲应力.
- 较高的药物负载增加了药片表面粗度和水友性 (较低的接触角度).
- 药物度增加导致更大的胀和凝层形成,阻碍更高剂量 (40毫克) 的药物释放,而较低剂量 (10毫克) 的药物释放速度更快.
结论:
- 药物含量显著影响3D打印PEO片的表面特性,胀行为和释放概况.
- 溶解成像为优化3D打印剂型提供了关于胀和通道形成的宝贵见解.
- 这项研究强调了FDM3D打印在制造有控制释放特性的定制口服药物输送系统方面的潜力.
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