开放访问的测量不确定性计算器MUCalc及其应用在使用高性能液态染色学 (HPLC) 测量片中的埃蒂佐拉姆的量化
Joyce K Klu1, Roberto Puch-Solis1, Roy Mudie1
1Leverhulme Research Centre for Forensic Science, School of Science and Engineering, University of Dundee, Nethergate, Dundee DD2 1HD, Scotland, UK.
Science & justice : journal of the Forensic Science Society
|January 24, 2025
概括
法医毒理学家现在可以使用MUCalc,一个新的开放访问软件,轻松估计测量不确定性. 该工具通过量化方法的不确定性来支持准确的药物分析,有助于法律披露和培训.
科学领域:
- 法医毒理学 法医毒理学
- 分析化学 分析化学
- 测量科学 测量科学 测量科学
背景情况:
- 对法医毒理学家和药物化学家来说,测量不确定性评估至关重要.
- 目前的实践指南建议在不确定性估计中采用自下而上的方法.
- 现有的方法可能缺乏透明度和实践人员的易用性.
研究的目的:
- 开发一个开放访问的软件工具,MUCalc,用于估计法医分析中的测量不确定性.
- 提供基于自下而上的方法的透明,用户友好的平台.
- 支持法医从业人员满足认证要求和法律披露标准.
主要方法:
- 开发实施自下而上的方法的MUCalc软件.
- 不确定性元件的量化:样本均性,方法精度,校准和样本准备.
- 根据ISO/IEC指南98,GUM,EURACHEM和UKAS标准计算组合和扩展的不确定性.
主要成果:
- MUCalc提供了所有公式和逐步计算的透明"白盒"显示.
- 该软件促进了对不确定性计算的理解,交叉检查和培训.
- 已证明使用MUCalc来量化etizolam度分析中的不确定性.
结论:
- MUCalc为法医实验室提供了一种有价值,易于使用的工具,用于估计测量不确定性.
- 软件的透明度提高了法律披露和教育目的的可靠性.
- 在法医毒理学中,MUCalc支持准确和可辩护的分析结果.
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