探索中性粒细胞作为心脏代谢疾病中的治疗点
Mattia Albiero1, Andrea Baragetti2
1Department of Surgery, Oncology, and Gastroenterology, University of Padova, Padua, Italy; Regional Center for the Cellular Therapy of Diabetes, University Hospital of Padova, Padua, Italy; Veneto Institute of Molecular Medicine, Laboratory of Experimental Diabetology, Padua, Italy.
Trends in pharmacological sciences
|January 24, 2025
概括
目前的糖尿病和心血管疾病疗法忽略了炎症. 本综述探讨了关键炎症细胞中性粒细胞如何受到治疗的影响,并讨论了结合疗法以向炎症以更好地管理心脏代谢疾病.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢疾病 代谢疾病
- 心血管研究研究心血管研究
背景情况:
- 目前糖尿病和动脉样硬化心血管疾病 (ACVD) 的治疗主要针对代谢因素.
- 这些疗法往往无法控制全身炎症,这是疾病发展和进展的关键因素.
- 中性粒细胞在炎症和心脏代谢疾病中发挥着重要作用,具有适应性免疫代谢功能.
研究的目的:
- 审查当前心脏代谢疾病治疗对中性粒细胞炎症通路的影响.
- 探索潜在的治疗策略,将既定治疗方法与重新设计的抗炎药物结合起来.
- 突出中性粒细胞在炎症和疾病进展中的作用.
主要方法:
- 对糖尿病和ACVDs当前治疗方法的文献综述.
- 分析中性粒细胞对能量基质的反应中的免疫代谢重编程.
- 检查参与中性粒细胞炎症反应的分子通路.
- 对抗炎症疗法的探索,以潜在的重新利用.
主要成果:
- 对于心脏代谢疾病的正规疗法会影响中性粒细胞的炎症通路.
- 中性粒细胞的功能由可用的能量基质调节,影响炎症和组织平衡.
- 已建立的治疗方法可能对中性粒细胞驱动的炎症有未知的影响.
- 现有疗法和抗炎药物之间的协同作用是合理的.
结论:
- 中性粒细胞是心脏代谢疾病的核心参与者,受到疾病状态和治疗的影响.
- 向中性粒细胞功能为糖尿病和ACVDs中的全身炎症管理提供了一个有希望的途径.
- 将传统治疗与新型抗炎策略相结合,可以提高心脏代谢疾病的治疗结果.
相关概念视频
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.3K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.3K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
376
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
376
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
55
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
55
01:38Inflammation
52.4K
Overview
52.4K
01:16Antianginal Drugs: Nitrates and β-Blockers
511
In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow....
511