相关实验视频

Updated: May 3, 2026

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome

Published on: October 3, 2018

在全身性硬化症中进行自身干细胞移植:4例:

Marta de la Rubia Navarro¹, Samuel Leal Rodríguez¹, José Andrés Román Ivorra¹

¹Servicio de Reumatología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Reumatologia clinica

|January 24, 2025

概括

自主造血干细胞移植 (AHSCT) 在全身性硬化症 (SSc) 方面表现有前途. 这种疗法改善了皮肤状况,并维持了四名患者的肺功能,具有可管理的安全性.

科学领域:

风湿病学和免疫学
血液学和干细胞移植

背景情况:

系统性硬化症 (SSc) 是一种慢性自身免疫性疾病,其特征是皮肤和内部器官纤维化.
目前用于快速渐进的扩散性SSc的治疗方法的疗效有限,副作用很大.
自主造血干细胞移植 (AHSCT) 是严重自身免疫性疾病的新兴治疗选择.

研究的目的:

评估四名接受AHSCT的SSc患者的临床和血清学特征.
评估之前和当前的治疗方法,以及与SSc.中AHSCT相关的不良事件.
确定AHSCT作为SSc.治疗选择的安全性和有效性.

主要方法:

一项描述性,横截面研究,涉及四名符合ACR/EULAR 2013标准的SSc患者.
从2014年到2023年收集临床和血清学数据,包括治疗细节和不良事件.
使用修改的罗丹恩皮肤评分 (mRSS) 评估皮肤参与和通过肺部一氧化碳 (DLCO) 扩散能力的肺功能.

主要成果:

四名女性患者的平均年龄为49岁,接受了AHSCT,诊断后平均为32.5个月.
观察到皮肤状况显著改善 (平均mRSS减少14.75).
肺功能 (DLCO) 保持稳定;一名患者在移植后出现了可控的肺炎.

结论:

对于快速进展的扩散性SSc.患者来说,AHSCT是一种可行的治疗选择.
该程序在这个队列中显示出了有利的安全概况.
在SSc患者中,AHSCT可能会导致显著的临床改善.

关键词:

扩散性系统性硬化症扩散性系统性硬化症系统性扩散性硬化症血造细胞移植血造细胞移植罗丹恩的得分罗丹恩的得分骨髓移植骨髓移植

更多相关视频

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

In Vivo Osteo-organoid Approach for Harvesting Therapeutic Hematopoietic Stem/Progenitor Cells

Published on: February 16, 2024

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Author Spotlight: Exploring the Lifespan Dynamics of Healthy Human Hematopoiesis

Published on: December 8, 2023

相关概念视频

Forced Transdifferentiation

Forced Transdifferentiation

Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...

Bone Marrow Sampling and Transplants

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...