相关实验视频
Updated: May 31, 2025
07:42
Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
18.1K
运动对化疗诱导的外周神经病变的影响:系统性审查和元分析
Anabela Amarelo1, Marisa Cristina Correia da Mota2, Bruno Luís Pires Amarelo2
1Gaia-Espinho Local Health Unit, Vila nova de Gaia, Portugal; Doctoral Program in Nursing, Department of Nursing, Abel Salazar Institute of Biomedical Sciences (ICBAS), Porto, Portugal; Association for the Investigation of Supportive Care in Oncology (AICSO), Porto, Portugal.
概括
运动显著改善化疗诱导的外围神经病变 (CIPN) 症状和生活质量. 对于患有CIPN.癌症的癌症患者,建议进行结构化的运动计划.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 运动科学 运动科学
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是癌症治疗的常见和衰弱的副作用.
- CIPN显著影响患者的生活质量,身体功能和执行日常活动的能力.
- 目前对CIPN的管理策略有限,突出显示需要有效的支持性干预.
研究的目的:
- 系统地审查和综合有关身体炼对CIPN的影响的证据.
- 评估各种运动干预措施在控制CIPN症状方面的有效性.
- 为整合运动与癌症治疗提供基于证据的建议.
主要方法:
- 系统审查和元分析遵循乔安娜·布里格斯研究所 (JBI) 和PRISMA指南.
- 在Medline,CINAHL,SportDiscus和Scopus数据库中进行全面的文献搜索 (开始至2024年3月).
- 包括12项与928名参与者的研究,分析了各种运动干预措施 (有氧,抵抗,平衡,组合).
主要成果:
- 使用FACT/GOG-Ntx尺度对五项研究的元分析显示,神经病症症状显著改善 (SMD=0.50,95%CI:0.26,0.74),有利于运动.
- 低异质性 (I2 = 2%) 表明体育炼在不同研究中具有一致的积极影响.
- 对12项研究的描述性分析显示,对感知到的CIPN严重程度,身体功能,平衡,ADL表现,疼痛和生活质量有好处.
结论:
- 身体炼对经历化疗诱导的外围神经病变的患者有显著的益处.
- 结构化的炼计划在缓解CIPN症状和改善整体幸福感方面表现有前途.
- 将运动干预措施纳入标准瘤治疗计划得到了当前证据的支持.
相关概念视频
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
147
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
147
01:20Exercise and Cardiovascular Response
721
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
721
02:49Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
173
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
173
01:17Exercise and Cardiac Output
901
Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
Sustained exercise increases the muscles' oxygen demand, which can be...
901