在患有转移性结肠直肠癌的患者中,基于aflibercept和基于bevacizumab的二线治疗方案:来自多中心队列的倾向性评分加权分析
Jessica Lucchetti1, Lorenzo Angotti2, Alessandro Parisi3
1Operative Research Unit of Medical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Clinical colorectal cancer
|January 24, 2025
概括
对于转移性结直肠癌 (mCRC),基于贝瓦齐祖马布的疗法在二线治疗中显示出优异的结果,而不是基于阿弗利塞普的治疗方法. 这在患有KRAS/NRAS和BRAF野生型瘤的患者中尤其明显,证明了改善的生存率和应答率.
科学领域:
- 在瘤学瘤学.
- 医学研究 医学研究
- 临床试验 临床试验
背景情况:
- 转移性结直肠癌 (mCRC) 的二线治疗选择包括aflibercept和基于贝瓦西祖马布的疗法.
- 在这种情况下,没有直接的比较研究确定了mCRC的最佳抗血管性策略.
研究的目的:
- 在mCRC患者中,比较基于bevacizumab的二线治疗方案与基于aflibercept的治疗方案的临床疗效.
- 根据特定瘤突变 (KRAS/NRAS/BRAF野生型和KRAS/NRAS突变) 分析治疗结果.
主要方法:
- 进行了一项多中心,回顾性,观察性研究.
- 包括348名接受二线治疗的mCRC患者.
- 对整体队列的结果进行了分析,并按KRAS/NRAS/BRAF突变状态分层.
主要成果:
- 与bevacizumab相比,基于aflibercept的疗法与死亡和疾病进展的风险增加以及客观响应率 (ORR) 的降低有关.
- 在KRAS/NRAS和BRAF野生型队列中,贝瓦齐祖马布显示了显著更长的整体存活 (OS),无进展存活 (PFS) 和更高的ORR.
- 在KRAS/NRAS突变队列中,贝瓦西祖马布也显示了更长的生存期.
结论:
- 建议在mCRC的二线治疗中使用基于贝瓦西祖马布的疗法,而不是基于阿弗利塞普的疗法.
- 贝瓦齐祖马布的益处在患有KRAS/NRAS和BRAF野生型瘤的患者中尤为明显.
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