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神经纤维光链水平在神经元表面抗体相关的自身免疫脑炎:一个系统性审查和元分析

Qi-Lun Lai¹, Meng-Ting Cai², Er-Chuang Li³

¹Department of Neurology, Zhejiang Hospital, Hangzhou, China.

Translational psychiatry

|January 24, 2025

概括

神经纤维光链 (NfL) 的水平在神经元表面抗体相关的自身免疫脑炎 (NSAE) 患者的血清和脑脊液 (CSF) 中升高. 然而,NfL水平与NSE患者的疾病严重程度或其他临床特征无关.

科学领域:

神经免疫学神经免疫学
神经学神经学
生物标志物研究生物标志物研究

背景情况:

神经元表面抗体相关的自身免疫脑炎 (NSAE) 涉及针对神经元抗原的自身抗体.
神经纤维光链 (NfL) 作为NSAE生物标志物的作用尚不清楚,研究结果相互矛盾.
升高的NfL水平可能表明神经元在各种神经疾病中的损伤.

研究的目的:

系统地审查和对NSEE中NfL水平的现有研究进行元分析.
评估NfL度在NSAE患者的血清和脑脊液 (CSF) 中.
确定NfL水平与NSEE的临床/准临床特征之间的关联.

主要方法:

在PubMed,知识网络和Cochrane图书馆的系统文献搜索.
包括13项报告NfL水平在NSAE患者的研究.
随机效应元分析,以综合有关NfL水平及其相关性的数据.

主要成果:

与对照组相比,NSAE患者的NfL血清水平显著更高 (SMD=0.909,95% CI:0.536-1.282).
与对照组相比,NSAE患者的CSF NfL水平明显升高 (SMD = 0.897,95% CI:0.508-1.286).与对照组相比,NSAE患者的CSF NfL水平明显升高.
在NfL水平和疾病严重程度,预后或神经成像/EEG/CSF发现之间没有发现显著的相关性.

结论:

血清和CSFNfL水平在NSAE患者中升高.
在NSAE中NfL水平与临床严重程度或临床准指标没有显著关联.
NfL可以作为NSAE中神经元损伤的一般标志物,但缺乏疾病特征的特异性.

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