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Updated: May 31, 2025

Visualization of Mitochondrial Respiratory Function using Cytochrome C Oxidase / Succinate Dehydrogenase COX/SDH Double-labeling Histochemistry
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SLC25A38对于线粒体氧化5'-酸盐 (PLP) 积累是必需的

Izabella A Pena1,2,3, Jeffrey S Shi4,5, Sarah M Chang5,6,7

  • 1The Picower Institute for Learning and Memory, MIT, Cambridge, MA, USA. ipena@cheo.on.ca.

Nature communications
|January 24, 2025
PubMed
概括

研究人员确定SLC25A38是调节线粒体pyridoxal 5'-phosphate (维生素B6的活性形式) 的关键蛋白质. 它的损失损害了细胞增殖,影响了单碳代谢,为先天性 sideroblastic 贫血提供了洞察力.

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Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
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Sorting of outer membrane proteins:
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