身体构成与晚期非小细胞肺癌患者的整体存活率之间的关联
Liang Fu1, Haiming Ding1, Liupei Mo1
1Department of Radiology, The First Affiliated Hospital of Guangxi Medical University, No.6 Shuangyong Road, Nanning, 530021, Guangxi, China.
Scientific reports
|January 24, 2025
概括
来自CT扫描的骨肌肉和脂肪组织测量可以预测高级非小细胞肺癌 (NSCLC) 的存活率. 较高的皮下脂肪指数 (SFI) 和较低的准脊椎肌肉密度 (PVMD) 与NSCLC患者的整体存活率 (OS) 的改善有关.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 营养科学 营养科学
背景情况:
- 营养状况显著影响癌症预后.
- 在高级非小细胞肺癌 (NSCLC) 中,CT扫描的骨肌肉和脂肪组织测量的预后价值存在有限的研究.
研究的目的:
- 调查诊断时通过CT扫描测量的身体组成参数与晚期NSCLC患者的整体存活率 (OS) 之间的关联.
主要方法:
- 从425名晚期NSCLC患者的CT图像进行了回顾性分析.
- 使用诸如胸肌指数 (PMI),胸肌密度 (PMD),皮下脂肪指数 (SFI),皮下脂肪密度 (SFD),甲脊椎肌指数 (PVMI) 和甲脊椎肌密度 (PVMD) 等指数量化骨肌肉和皮下脂肪.
- 对临床变量进行调整的多变量考克斯回归分析.
主要成果:
- 较高的SFI与死亡风险明显降低相关 (HR=1.410,P=0.026).
- 较低的PVMD显著与改善的整体存活率相关 (HR=0.762,P=0.048).
- 身体质量指数 (BMI) 与整体存活率没有显著关联.
结论:
- 来自CT的身体组成参数,特别是SFI和PVMD,为晚期NSCLC患者提供了精确的预后信息.
- 这些CT测量参数优于BMI来预测这一患者群体的整体存活率.
- 在先进的NSCLC中增加的OS与更高的SFI和较低的PVMD有关.
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