在生命早期便中升高的利波卡林-2水平与母亲的炎症性肠病诊断有关
Leonid Tarassishin1, Taegyu Kim1, Jianzhong Hu1,2
1Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1425 Madison Ave, New York, NY, 10029, USA.
Digestive diseases and sciences
|January 24, 2025
概括
患有炎症性肠病 (IBD) 的母亲出生的婴儿在生命早期有更高的便卡林-2 (LCN2) 水平. 纯母乳养与新生儿的较低LCN2相关.
科学领域:
- 围产期健康 围产期健康
- 胃肠病学 胃肠病学
- 微生物组研究的研究.
背景情况:
- 便中的脂卡林-2 (LCN2) 是中性粒细胞激活的生物标志物,在炎症性肠病 (IBD) 中升高.
- 怀孕期间和生命早期LCN2的动态变化尚未得到充分理解.
- 这项研究调查了与母亲IBD,婴儿养和肠道微生物群相关的LCN2水平.
研究的目的:
- 鉴定IBD孕妇及其后代的便LCN2水平.
- 评估母体IBD诊断和婴儿养习惯对LCN2水平的影响.
- 探索LCN2和肠道微生物群组成之间的相关性.
主要方法:
- 前性队列研究 (MECONIUM) 分析了559个有IBD和对照的孕妇及其后代的便样本.
- 使用已建立的测定方法测量LCN2水平,跨越怀孕和生命早期的时间点.
- 通过16S rRNA基因测序分析肠道微生物组成;统计分析包括线性混合效应模型和后勤回归.
主要成果:
- 与对照人群相比,患有IBD的母亲在整个怀孕期间表现出更高的LCN2.
- 患有IBD的母亲的后代在3个月,1年和4年时显示显著升高的LCN2.
- 后代LCN2准确预测了母亲IBD状态 (>85%准确率在1岁和4岁);发现了LCN2和IBD相关细菌之间的相关性.
- 纯母乳养与婴儿早期较低的LCN2有关.
结论:
- 患有IBD母亲的婴儿在早期生活中LCN2升高,受母乳养的影响.
- 在母亲和婴儿中,LCN2水平与IBD相关的微生物种群相关.
- 需要进一步的研究来阐明早期生活中LCN2升高的生物学驱动因素和健康影响.
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