在消化系统癌症中全身炎症反应指数的预后价值:系统性审查和元分析
Zuo-Hu Niu1, Li Lin2, Hong-Ye Peng3
1Department of Infections, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
BMC gastroenterology
|January 25, 2025
概括
系统性炎症反应指数 (SIRI) 的升高与消化系统癌症 (DSC) 的较差结果有关. 这种标志物显示出预测DSC患者的生存潜力,有助于临床决策.
科学领域:
- 在瘤学瘤学.
- 炎症生物标志物 炎症生物标志物
- 癌症预后 癌症预后
背景情况:
- 消化系统癌症 (DSC) 越来越令人担忧,对癌症死亡率有很大影响.
- 系统性炎症反应指数 (SIRI) 正在成为各种DSC类型预后的关键指标.
研究的目的:
- 评估系统性炎症反应指数 (SIRI) 在被诊断为消化系统癌症 (DSC) 的患者的预后意义.
主要方法:
- 进行了一项元分析,包括34项队列研究,共9628名参与者,分析治疗前的SIRI水平.
- 使用随机效应模型合成了危险比率 (HR) 和95%置信区间 (CI).
- 评估了总生存率 (OS),无进展生存率 (PFS),无疾病生存率 (DFS),进展时间 (TTP) 和疾病特异性生存率 (DSS).
主要成果:
- 提升的SIRI与较差的OS (HR=1.98),PFS (HR=2.36),DFS (HR=1.80),TTP (HR=2.03) 和DSS (HR=1.99) 显著相关.
- 对于OS和PFS,发现了显著的异质性,但对于DFS,TTP或DSS则没有.
- 治疗后的SIRI变化也与生存结果相关,增加与预后较差,减少与改善结果相关.
结论:
- 系统性炎症反应指数 (SIRI) 是消化系统癌症 (DSC) 的一个有价值的预后生物标志物.
- 较高的SIRI水平表明临床结果较差,为患者的生存提供了一个预测工具.
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