针对HGF/c-MET信号来调节瘤微环境:对抗瘤免疫逃避的含义
Yang Xia1,2, Chunye Huang1,2, Min Zhong3
1Department of Oncology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, Jiangxi Province, 330006, China.
Cell communication and signaling : CCS
|January 25, 2025
概括
肝细胞生长因子 (HGF) 和其受体 (c-MET) 途径失衡促进瘤. 将c-MET抑制剂与抗PD-1/PD-L1等免疫检查点抑制剂 (ICI) 结合起来,可以提高癌症治疗的疗效,特别是在MET驱动的瘤中.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 肝细胞生长因子 (HGF) 和其受体 (c-MET) 信号传递对正常细胞功能至关重要.
- HGF/c-MET通路的失调与瘤的发展和进展有关.
- 免疫检查点抑制剂 (ICI),如抗PD-1/PD-L1疗法,在一些癌症患者中提供持久缓解.
研究的目的:
- 阐明c-MET信号通路与瘤微环境 (TME) 之间的复杂关系.
- 研究MET失调如何影响抗PD-1/PD-L1免疫疗法的疗效.
- 探索c-MET抑制剂与ICI结合的潜力,以提高癌症治疗结果.
主要方法:
- 检查MET失衡和ICI耐药机制的临床前研究的综述.
- 对c-MET和PD-1/PD-L1抑制剂联合使用的临床和临床前数据的分析.
- 检查异常HGF/c-MET信号对TME调制和PD-L1表达的影响.
主要成果:
- 通过各种机制,MET通路的失调可以阻碍抗PD-1/PD-L1疗法的有效性.
- 异常的HGF/c-MET激活会影响癌细胞中的TME和PD-L1表达.
- 证据支持c-MET抑制剂与ICI结合的协同潜力.
结论:
- 针对HGF/c-MET通路与免疫疗法一起,可以克服抵抗机制.
- 联合c-MET抑制和ICI治疗显示出治疗高PD-L1表达的MET驱动瘤的前景.
- 这种治疗策略有可能改善瘤学患者的治疗结果.
相关概念视频
The Tumor Microenvironment
6.5K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.5K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Tumor Immunotherapy
466
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
466
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K


