抗生素暴露与健康期婴儿的肠道微生物组最少的干扰有关
Alain J Benitez1,2, Ceylan Tanes1, Elliot S Friedman3
1Division of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, 19146, USA.
Microbiome
|January 25, 2025
概括
婴儿早期接触抗生素对肠道微生物群的影响很小,其影响比母乳养或婴儿年龄的影响要小. 这些短期变化并没有长期持续下去.
科学领域:
- 微生物组研究的研究.
- 儿科卫生健康 儿科卫生健康
- 免疫学 免疫学 免疫学
背景情况:
- 婴儿肠道微生物组对于免疫发育和长期健康至关重要.
- 早期接触抗生素可能会破坏微生物组的发育,可能导致不良健康结果.
- 了解这些影响对于婴儿健康策略至关重要.
研究的目的:
- 调查抗生素暴露与婴儿肠道微生物组合和胆酸概况之间的关联.
- 为了比较抗生素的影响与其他因素,如母乳养和婴儿年龄.
主要方法:
- 对323名健康的非裔美国婴儿进行前性纵向分娩队列研究.
- 用于微生物组分析的步枪元基因组学测序.
- 液体染色学-质谱学用于胆酸分析.
- 短期副研究,以评估抗生素后的直接影响.
主要成果:
- 抗生素暴露显示微生物群差异很小,母乳养的影响更大.
- 在2周内观察到短期效应 (例如,Bifidobacterium bifidum减少),但没有持续.
- 没有发现抗生素暴露与抗生素耐药性基因增加或胆酸概况改变之间存在关联.
- 婴儿年龄与四种微生物物种的差异有关.
结论:
- 来自短期和长期抗生素暴露的肠道微生物组干扰是可检测的,但不如母乳养和婴儿年龄的干扰那么重要.
- 婴儿的肠道微生物群对典型的抗生素暴露有弹性.
- 进一步的研究可以为婴儿肠道健康提供有针对性的干预措施.
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