住院期间呼吸支对长期COVID的功能结果的影响:对前性队列研究的后期分析
Camila Miriam Suemi Sato Barros do Amaral1,2, Jefferson Valente2, Cássia da Luz Goulart1
1Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus 69040-000, Brazil.
International journal of environmental research and public health
|January 25, 2025
概括
这项研究发现,虽然急性COVID-19期间的侵入性机械通风导致肌肉损失和120天后呼吸力降低,但总体功能能力和呼吸功能根据所接受的呼吸支持水平并没有显著差异. 这对理解COVID-19后恢复产生了影响.
科学领域:
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
- 康复医学 康复医学 康复医学
背景情况:
- 后急性COVID-19综合征 (PACS) 在急性感染后呈现持续症状和身体残疾.
- 了解长期功能结果对于患者的康复和康复策略至关重要.
研究的目的:
- 为了确定COVID-19后120天的功能能力和呼吸功能是否根据急性住院期间的呼吸支持水平而有所不同.
- 分析患者组之间的身体组成,呼吸肌肉强度,肺功能和功能能力的差异.
主要方法:
- 一组118名在医院住院的COVID-19患者从疫苗前的时代被跟踪了120天.
- 患者被分为三个组:非侵入性氧气疗法 (OTG),侵入性机械通风 (IMV) 和室内空气 (RAG).
- 评估包括螺旋测量,DASI得分,手术真空测量 (MIP/MEP),6分钟步行测试 (6MWT) 和手握强度.
主要成果:
- IMV组年龄较大,有更多的ICU入院和更长的住院时间.
- 在120天后,在螺旋测量,DASI,人体真空测量,6MWT或手握强度之间没有发现显著差异.
- 与RAG相比,IMV组显示身体肌肉质量的显著减少,最大吸入和呼气压力 (MIP/MEP) 降低.
- 与RAG相比,OTG组也显示了较低的MIP和MEP.
结论:
- 在COVID-19住院后120天的功能结果与急性疾病期间的氧气补充水平没有显著的关联.
- 虽然严重的通风支持 (IMV) 影响了肌肉质量和呼吸压力,但在这个时间点,整体功能恢复在支持水平之间看起来是可比的.
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