在患有扩展性心肌病的患者中进行层特异性应变分析
Despina-Manuela Toader1, Alina Paraschiv2, Georgică Târtea3,4
1EuroEchoLab, Craiova Cardiology Center, Emergency Hospital Craiova, 200642 Craiova, Romania.
Biomedicines
|January 25, 2025
概括
在扩张性心肌病中,层特异性应变分析可以预测心脏死亡率. 心内膜周围应变 (CSPMend) 是识别两年内死亡风险较高的患者的关键指标.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 心脏成像 - - 心脏成像
背景情况:
- 扩张性心肌病 (DCM) 是心力衰竭的一个重要原因.
- DCM的病因 (缺血性与非缺血性) 影响疾病的表现.
- 预测心力衰竭脱补偿的DCM患者的心脏死亡率至关重要.
研究的目的:
- 根据病因学来评估DCM中的特定层菌株.
- 为了确定纵向和周围层应变是否预测DCM患者的心脏死亡率.
- 在为期两年的随访中评估菌株参数的预后价值.
主要方法:
- 招募了97名DCM患者 (LVEF ≤40%),按缺血病 (n=51) 和非缺血病 (n=46) 的病因划分.
- 在补偿心力衰竭期间执行常规和2D斑点跟踪回声心脏图 (2D-STE).
- 评估层特定的纵向和周围应变 (内心脏,心肌中部,心脏上部) 和计算的梯度.
主要成果:
- 非缺血性DCM患者的全球和层压力比缺血性患者低.
- 在非幸存者中观察到GLS,GLSend,GLSend-GLSepi,CSPMend,CSPMend-CSPMepi,CSAP,CSAPend和CSAPend-CSAPepi的减少.
- 多变量分析发现CSPMend是两年死亡率的独立预测因素; -10.8%的切断值显示了80%的灵敏度和61.05%的特异性.
结论:
- 层特异性菌株分析显示,非缺血性DCM和非幸存者的值有所降低.
- 心内膜周围应变 (CSPMend) 成为预测DCM患者死亡风险的最敏感参数.
更多相关视频
12:12Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
15.9K
09:05Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
19.4K
相关概念视频
01:22Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...