孕产妇的宏观营养素摄入量和妊娠期糖尿病相关风险:来自BORN2020研究的结果
Antigoni Tranidou1,2, Ioannis Tsakiridis1, Emmanuela Magriplis3
13rd Department of Obstetrics and Gynecology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Biomedicines
|January 25, 2025
概括
超过推的母体宏观营养素摄入量,特别是怀孕期间增加的蛋白质,纤维和单不和脂肪酸,与更高的妊娠糖尿病 (GDM) 风险有关.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 流行病学 流行病学
背景情况:
- 有限证据表明,母亲摄入的宏观营养素与妊娠期糖尿病 (GDM) 风险之间的关联是有限的.
- 这项研究调查了怀孕前和怀孕期间的宏观营养素摄入与GDM风险相关,参考欧洲食品安全局 (EFSA) 的饮食参考值 (DRV).
研究的目的:
- 评估母亲 (怀孕前和怀孕期间) 大量营养素摄入量与患妊娠期糖尿病 (GDM) 的风险之间的关联.
主要方法:
- 来自希腊BORN2020孕妇队列的前性数据收集 (n=797).
- 使用多项逻辑回归分析来评估宏观营养素摄入量与GDM之间的关联,并根据混因素进行调整.
- 宏观营养素摄入量与EFSA的DRVs进行了比较.
主要成果:
- 超过EFSA建议的更高的妊娠前能量摄入量与增加的GDM风险相关 (aOR = 1.99).
- 在妊娠中期,增加的食纤维,蛋白质摄入量和能量中的蛋白质百分比与更高的GDM风险有关.
- 从怀孕前到怀孕期间增加的食纤维,蛋白质,脂肪,植物蛋白,动物蛋白和单不和脂肪酸 (MUFA) 摄入量与增加的GDM风险显著相关.
结论:
- 超过EFSA上限的孕产妇能量摄入量与更高的GDM风险有关.
- 在怀孕期间增加蛋白质,MUFA和纤维的摄入量,超过推水平,可能会对妊娠产生负面影响,并增加GDM的可能性.
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.2K
Pathophysiology of Diabetes
854
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
854
Diabetes Mellitus: Overview and Type I Subtype
2.4K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.4K
Diabetes: Symptoms, Diagnosis, and Complications
500
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
500
Overview of Carbohydrate Metabolism
694
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
694
Carbohydrate Metabolism
10.8K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
10.8K


