维生素D缺乏作为糖尿病视网膜病变的危险因素:系统性审查和元分析
Claudia Elena Petrea1, Laura Andreea Ghenciu2,3, Roxana Iacob1,4,5
1Department of Anatomy and Embriology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania.
Biomedicines
|January 25, 2025
概括
较低的维生素D水平与糖尿病视网膜病变 (DR) 的风险更高有关,这是视力丧失的主要原因. 这次审查表明,解决维生素D缺乏症可能有助于管理糖尿病并发症.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 糖尿病视网膜病变 (DR) 是全球视力损失的主要原因,与糖尿病相关.
- 除了骨健康之外,维生素D越来越多地被研究其在非骨疾病中的作用,如DR.
- 现有研究表明,维生素D状态与DR发展或进展之间存在潜在的关联.
研究的目的:
- 系统地审查和分析有关维生素D水平与糖尿病视网膜病变之间的关系的现有研究.
- 量化维生素D状况与患有DR的几率之间的关联.
- 为了探索DR严重程度不同阶段的维生素D水平.
主要方法:
- 对20项涉及22,408名参与者的研究进行了系统审查,其中包括9项研究在元分析中.
- 纳入标准侧重于具有不同的DR和非DR组的研究以及定量维生素D测量.
- 采用固定效应和随机效应模型进行聚合分析,以计算赔率比率 (OR) 并比较平均维生素D水平.
主要成果:
- 在较低的维生素D水平和DR的增加几率 (OR 1.15-1.17) 之间发现了显著的关联.
- 与没有DR的人 (19.71 ng/mL) 相比,DR患者的血清维生素D水平平均较低 (18.11 ng/mL).
- 随着DR严重程度的增加,维生素D水平逐渐下降,在增殖性DR中水平明显降低.
结论:
- 较低的维生素D水平与糖尿病视网膜病变的风险和严重程度的增加显著相关.
- 在DR人群中,维生素D缺乏的高患病率表明它可能是可修改的危险因素.
- 需要进一步的纵向研究来确定因果关系,并探索维生素D补充在DR管理中的治疗潜力.
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