相关实验视频

Updated: May 31, 2025

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model

Published on: January 13, 2023

治疗头部和部癌症的高素介导光动力疗法:系统性审查

Jakub Fiegler-Rudol¹, Natalia Zięba², Radosław Turski³

¹Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.

|January 25, 2025

概括

超素介导光动力疗法 (HY-PDT) 对头癌具有前景,可以选择性地杀死瘤细胞,并以最小的毒性调节免疫微环境. 需要进一步的临床试验来确认疗效.

科学领域:

在瘤学瘤学.
光动力学疗法光动力学疗法
癌症研究癌症研究

背景情况:

传统的头癌治疗具有很高的复发率,并影响生活质量.
光动力疗法 (PDT) 提供了一个有前途的替代方案,使用光敏剂,如hypericin.
超素选择性地准瘤细胞,最大限度地减少对健康组织的损伤.

研究的目的:

为了评估高素介导PDT (HY-PDT) 在头癌中的疗效.
阐明 HY-PDT 作用背后的机制.
评估HY-PDT对瘤微环境的影响.

主要方法:

按照PRISMA 2020指南进行系统的文献搜索.
包括临床前体外/体内研究和临床试验的HY-PDT的头癌.
对2000年1月至2024年12月期间发表的研究进行分析.

主要成果:

HY-PDT通过亡和亡,通过ROS生成,对状细胞癌显示出显著的细胞毒性.
超素在癌细胞中显示有选择性的吸收,与正常的角质细胞相比.
HY-PDT调节了瘤微环境,改变了细胞因子配置 (例如,增加IL-20,sIL-6R),可能增强抗瘤免疫力并减少转移.

结论:

HY-PDT是一种有希望的,对头癌的最小毒性治疗方法,诱导选择性瘤细胞死亡和免疫调节.
有令人鼓舞的临床前数据,但方法变化和有限的临床数据需要进一步研究.
需要进行大规模,标准化,随机的受控试验来验证HY-PDT的临床效用.

关键词:

灭症 (apoptosis) 是一种死亡的过程.细胞因子细胞因子头部和部癌症头部和部癌症过高氨酸的使用情况免疫调节免疫调节免疫调节光动力学疗法是一种光动力学疗法.

更多相关视频

Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy

Quail Chorioallantoic Membrane - A Tool for Photodynamic Diagnosis and Therapy

Published on: April 28, 2022

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

相关概念视频

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...