在终性缺血机器输血后,输血性肝脏阿基因酶1水平与早期的异位移植功能障碍有关
Giuseppina Basta1, Serena Babboni1, Daniele Pezzati2
1Institute of Clinical Physiology, National Research Council (CNR), Via Moruzzi 1, 56124 Pisa, Italy.
Biomedicines
|January 25, 2025
概括
阿基因酶-1 (ARG-1) 是一个有前途的生物标志物,用于预测肝移植中早期的异位移植功能障碍. 在机器输液过程中较高的ARG-1水平表明移植活力较差,有助于移植决策.
科学领域:
- 移植免疫学 移植免疫学
- 器官保存技术 器官保存技术
- 发现生物标志物的发现.
背景情况:
- 循环死亡 (DCD) 肝移植后捐赠的使用越来越多,这取决于常温区域输液 (NRP) 和机器输液 (MP).
- 需要预测性生物标志物来评估NRP后的DCD移植活力,在移植之前.
研究的目的:
- 在接受NRP的DCD肝移植中确定预测性生物标志物.
- 在NRP后,比较常温机器输液 (NMP) 和双低温氧化输液 (D-HOPE) 之间的结果.
主要方法:
- 在NRP,MP和移植后期间从32个DCD肝移植中收集生物标志物.
- 评估了氧化应激,肝损伤,炎症,再生和自标志物.
- 利用接收器操作特征 (ROC) 分析来评估早期全移植功能障碍 (EAD) 的生物标志物预测准确性.
主要成果:
- 高氨酶-1 (ARG-1) 水平与肝损伤相关,并预测了EAD (AUC = 0.713).
- 与NMP相比,D-HOPE的脂质过氧化 (TBARS) 高于NMP,这表明氧化环境更强.
- 在NMP和D-HOPE之间,代谢物和炎症标志物配置不同,再生标志物在输液过程中增加.
结论:
- 阿基纳-1 (ARG-1) 显示出作为DCD肝移植活力评估的早期生物标志物的显著潜力.
- perfusion 期间的生物标志物分析可以支持肝移植的及时决策.
- 输液策略会影响移植的氧化和炎症环境.
相关概念视频
Blood Transfusion and Agglutination
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...
Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...


