状细胞疾病中的睡眠行为:系统性审查和元分析
Melanie Koelbel1, Fenella J Kirkham1
1Developmental Neurosciences Unit, Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK.
Children (Basel, Switzerland)
|January 25, 2025
概括
睡眠行为障碍在状细胞病 (SCD) 中很常见. 这次审查发现睡眠模式和持续时间不一致,突出了儿童SCD队列中标准化睡眠评估方法的需要.
科学领域:
- 血液学 血液学 血液学
- 睡眠医学 睡眠医学
- 儿科 儿科 儿科
背景情况:
- 状细胞疾病 (SCD) 经常与睡眠行为障碍和睡眠呼吸障碍 (SDB) 相关.
- 之前的系统性审查集中在SDB上,因此需要专门审查SCD的睡眠行为.
- 了解睡眠行为对于管理SCD患者的整体健康至关重要.
研究的目的:
- 对患有状细胞疾病的个体进行睡眠行为的系统审查和元分析.
- 综合当前关于儿童SCD队列睡眠模式的研究,包括总睡眠时间 (TST) 和睡眠开始延迟 (SOL).
- 确定有关SCD睡眠评估现有文献中的空白和局限性.
主要方法:
- 根据PRISMA指南进行了全面的文献搜索,包括所有语言和出版物类型,直到2022年2月.
- 在儿科SCD群体中,确定了31项使用多睡眠学,动作学和问卷/日记的研究.
- 在数据允许的情况下,进行了元分析,并对SCD患者和健康对照进行了比较.
主要成果:
- 总睡眠时间 (TST) 随着年龄的增长而减少,睡眠开始延迟 (SOL) 在儿科SCD队列中增加.
- 在不同的测量方法 (自我报告与客观措施) 中观察到TST和SOL的差异,可能是由于父母的高估.
- 分析受到出版偏差和异质性的限制,在有限的比较中,在SCD患者和对照者之间没有发现TST或SOL的显著差异.
结论:
- 发现的显著异质性,主要归因于睡眠评估方法的变化,使SCD睡眠行为的解释变得复杂.
- 缺乏可靠的案例控制研究限制了最终的结论.
- 需要使用标准化和客观的睡眠评估工具进行进一步的研究,以解决现有的文献差距.
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