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在稳定HCC的ATZ/BEV治疗患者中添加局部治疗的有效性

Atsushi Hosui¹, Naoko Hayata¹, Tomohide Kurahashi¹

¹Department of Gastroenterology and Hepatology, Osaka Rosai Hospital, 1179-3 Nagasonecho, Kita Ward, Sakai 591-8025, Osaka, Japan.

|January 25, 2025

概括

将局部治疗添加到阿特佐利祖马布和贝瓦齐祖马布 (ATZ/BEV) 疗法,显著改善了肝细胞癌 (HCC) 患者稳定疾病的整体存活率. 这种组合为改善HCC治疗结果提供了一个有前途的治疗选择.

科学领域:

肝胆瘤学肝胆瘤学
医学瘤学医学瘤学
免疫治疗是一种免疫疗法.

背景情况:

阿特佐利祖马布和贝瓦齐祖马布 (ATZ/BEV) 组合治疗在不可切除的肝细胞癌 (HCC) 中显示出高疗效.
在患有稳定疾病 (SD) 的患者中,将局部治疗 (LRT) 添加到ATZ/BEV的益处的评估对于优化治疗策略至关重要.

研究的目的:

研究在患有稳定性疾病 (SD) 肝细胞癌 (HCC) 的患者中,将局部治疗添加到阿特佐利祖马布和贝瓦齐祖马布 (ATZ/BEV) 的疗效.
为了比较接受ATZ/BEV治疗的患者与没有额外的局部区域治疗之间的总生存率 (OS).

主要方法:

对105名无法切除的HCC患者的回顾性分析,这些患者接受了第一线ATZ/BEV或伦瓦替尼 (LEN) 治疗.
患有稳定疾病 (SD) 的患者接受了局部治疗 (通过导管动脉化学栓塞和/或射频移除).
使用修改后的RECIST标准来评估整体存活率 (OS).

主要成果:

与ATZ/BEV和局域治疗治疗的患者相比,与单独ATZ/BEV治疗的患者相比,患者的生存率显著增加 (p=0.0343).
没有观察到与lenvatinib治疗的患者有或没有局部区域治疗的显著OS差异.
五名接受ATZ/BEV治疗的患者加上过导管动脉化学栓塞和/或射频剥离,实现了完全响应 (CR).

结论:

将局部治疗 (TACE/RFA) 添加到ATZ/BEV中,有利于稳定疾病的HCC患者.
在ATZ/BEV治疗期间响应有限时考虑局部治疗可能会改善预后.
局部治疗可以通过对HCC的免疫调节来提高治疗结果.

关键词:

剥离剥离剥离剥离它们是Atezolizumab.这是bevacizumab的治疗方法.肝细胞癌是肝细胞癌.增强免疫力增强免疫力地方区域治疗疗法病情稳定病情稳定通过动脉的化学血栓化.

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