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Wiktor Szatkowski¹, Tomasz Kluz², Małgorzata Cieślak-Steć³

¹Department of Gynaecologic Oncology, Maria Sklodowska-Curie National Research Institute of Oncology Krakow Branch, 31-115 Kraków, Poland.

|January 25, 2025

概括

在波兰,子宫内膜癌 (EC) 阶段和分子概况显示出显著的区域差异. 标准化诊断对于改善患者的治疗结果和指导个性化子宫内膜癌治疗至关重要.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
病理学病理学病理学

背景情况:

全球子宫内膜癌 (EC) 发病率和死亡率的上升.
新兴的分子技术和FIGO 2023分类提供了精细的诊断.
需要对EC分类和分子亚型进行区域分析.

研究的目的:

在波兰东南部的瘤中心分析子宫内膜癌分类的变化.
评估EC患者中分子亚型和关键标记物 (POLE,MSI-H,p53) 的分布.
为了确定EC分期和分子造型的中心间差异.

主要方法:

在2022-2024年间诊断的461名EC患者的回顾性分析.
在FFPE组织上进行分子和免疫组织化学分析.
利用FIGO 2023分期和评估POLE突变,MSI-H和p53状态.

主要成果:

在FIGO 2023分期的统计学上显著的中心间差异,在中心1和中心4的早期诊断更高.
非特异分子形状 (NSMP) 是最常见的亚型 (51%).
观察到的MSI-H (13-36%),p53突变 (9-26%),POLE突变 (4%总体) 的变化.

结论:

波兰在EC分期和分子概况方面存在区域差异.
诊断资源,方法或瘤生物学方面的潜在差异有助于变异.
标准化协议和公平获得分子诊断对于优化EC患者的治疗结果至关重要.

关键词:

在DNA聚合酶epsilon中.菲戈2023年菲戈2023年在MSI中,它是MSI.这是子宫内膜癌的癌症.分子分类的分子分类.在 p53 里,p53 是一个 p53 的代码.

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