黑色素瘤中的女性瘤和免疫检查站封锁:我们今天在哪里?
Cha Len Lee1, Erika Martinez1, Diego Malon Gimenez1
1Division of Medical Oncology and Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON M5G 1Z5, Canada.
Cancers
|January 25, 2025
概括
免疫检查点抑制剂 (ICI) 改善了黑色素瘤的生存率,但引起了女性的生育问题. 本综述涉及黑色素瘤患者ICI治疗后的生殖健康,生育能力保护和怀孕风险.
科学领域:
- 在瘤学瘤学.
- 生殖医学 生殖医学
- 免疫治疗是一种免疫疗法.
背景情况:
- 黑色素瘤发病率在年轻人中正在上升,但由于免疫检查点抑制剂 (ICI),死亡率正在下降.
- 术前ICI,特别是PD-1抑制剂,改善了高风险黑色素瘤的无复发生存率.
- 越来越多的ICI使用引发了人们对生育能力和生殖健康的担忧.
研究的目的:
- 审查女性黑色素瘤患者免疫治疗后的生育实践.
- 确定关于ICI对生殖健康和胎儿发育的影响的文献空白.
- 综合关于怀孕计划和黑色素瘤治疗后复发风险的证据.
主要方法:
- 文献综述侧重于ICI治疗的黑色素瘤患者的共同生育能力.
- 综合了关于ICI毒性,生育能力保护和怀孕结果的数据.
- 在怀孕和免疫治疗的背景下分析黑色素瘤复发风险.
主要成果:
- 关于ICI在怀孕期间对母亲和胎儿的毒性,人类的数据有限.
- 在辅助免疫疗法后,围绕生育保护有效性和怀孕结果的不确定性.
- 怀孕相关黑色素瘤 (PAM) 和其管理的独特性质需要进一步调查.
结论:
- 需要进一步的研究来解决关于ICI对女性生殖健康和黑色素瘤幸存者的怀孕影响的不确定性.
- 对于正在接受ICI治疗的生育潜力的妇女来说,子生育咨询和生育保护至关重要.
- 了解与怀孕相关的黑色素瘤和复发风险对于最佳的患者管理至关重要.
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