患者的治疗模式和结果 晚期胆道癌症患者用基于吉米西塔的化疗治疗:一项回顾性研究
Farshid Dayyani1, Heide A Stirnadel-Farrant2, Jenny Hu3
1Division of Hematology/Oncology and Chao Family Comprehensive Cancer Center, University of California, Irvine, 200 S Manchester Avenue, Orange, CA 92868, USA.
Cancers
|January 25, 2025
概括
大多数晚期胆道癌患者 (aBTCs) 接受的化学疗程少于建议的8个周期的吉姆西塔加西斯普拉丁 (GemCis). 现实世界的数据显示,总体存活率有限,强调了对aBTCs的新疗法的需求.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床药理学 临床药理学
背景情况:
- 从历史上看,结合结合西斯 (GemCis) 的凝是治疗晚期胆道癌症 (aBTC) 的标准治疗方法.
- 目前的指导方针建议免疫治疗加上GemCis作为aBTCs的第一线治疗.
- 在ABC-02研究中确定的GemCis完成八个周期的临床可行性,需要在现实世界中进行验证.
研究的目的:
- 为了评估现实世界治疗模式和总生存率 (OS) 在美国接受一线基于凝胺的化疗的新生或复发aBTC患者.
- 评估能够在现实环境中完成全八轮GemCis化疗的患者比例.
- 为了确定与aBTCs的第一线基于gemcitabine的化疗相关的生存结果.
主要方法:
- 使用非识别的市场清晰度数据的回顾性观察队列研究.
- 纳入标准:在2016年1月至2022年3月期间,在美国被诊断患有新发症或复发性aBTCs的成年人开始基于gemcitabine的第一线化疗.
- 评估结果:治疗模式,完成的周期,停药时间和整体存活率 (OS).
主要成果:
- 总共分析了559名患者 (462名新生患者,97名复发的aBTC).
- 吉姆西斯 (GemCis) 是最常见的第一线治疗方案 (73.8% de novo,57.7%的复发).
- 接受的GemCis循环的中位数约为五次,中位时间停止治疗为4.6个月;大多数患者没有完成八个循环.
- 新生患者的中位寿命为14.2个月,复发性aBTCs的中位寿命为18.5个月.
结论:
- 在美国的现实环境中,GemCis仍然是先进胆道癌症的常见一线化疗.
- 很大一部分患者没有完成预期的8轮GemCis化疗.
- 有限的整体存活率强调了对aBTCs,包括新药和组合的更有效的治疗策略的迫切需要.
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