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Updated: May 31, 2025

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G蛋白结合受体17通过Gi/o-依赖机制在肠内分泌细胞中抑制类似葡萄糖的-1分泌

Jason M Conley1,2, Alexander Jochim1,2, Carmella Evans-Molina1,2,3,4

  • 1Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Biomolecules
|January 25, 2025
PubMed
概括

G蛋白结合受体17 (GPR17) 在肠道细胞中负面调节类似葡萄糖-1 (GLP-1) 的分泌. 信号传输主要涉及Gi/o通路,为代谢障碍提供潜在的治疗点.

关键词:
G蛋白结合受体 (GPCR) 是一种和是最重要的.循环AMP (cAMP) 的使用.糖尿病 糖尿病患者 糖尿病患者类似葡萄糖类1 (GLP-1)代谢性疾病是代谢性疾病.肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖 肥胖信号传导的信号传导.

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