在西班牙加泰罗尼亚的Staphylococcus caprae感染的临床和流行病学特征
Javier Díez de Los Ríos1,2,3,4,5, María Navarro6, Judit Serra-Pladevall5,6,7
1Internal Medicine Department, Multidisciplinary Inflammation Research Group, Hospital Universitari de Vic, 08500 Vic, Spain.
Microorganisms
|January 25, 2025
概括
斯塔菲洛科克卡普雷感染正在增加,皮肤和软组织感染是最常见的. 这种新兴的动物性传染病原体,通常与牲畜有关,仍然对关键抗生素敏感,但监测至关重要.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 动物性疾病是动物性疾病.
背景情况:
- 凝聚酶阴性葡萄球菌 (CoNS) 包括Staphylococcus caprae,一种主要与动物相关的细菌.
- 虽然S. caprae被认为是人类潜在的动物传染病原体,但对其感染的临床数据仍然很少.
- 了解S. caprae感染的流行病学和临床特征对于公共卫生至关重要.
研究的目的:
- 描述西班牙加泰罗尼亚的Staphylococcus caprae感染情况,比较城市和农村的医院环境.
- 确定与S. caprae感染相关的临床表现,患者人口统计和风险因素.
- 评估S. caprae感染的抗微生物敏感性模式和治疗结果.
主要方法:
- 追溯观察性研究分析了从2010年1月到2023年12月的临床记录.
- 包括从加泰罗尼亚农村和城市的两个医院诊断的所有S. caprae感染病例.
- 收集有关患者人口统计,感染类型,牲畜暴露,治疗和结果的数据.
主要成果:
- 确定了31例S. caprae感染病例,近年来有显著增加 (2017年以来为75%).
- 主要感染包括皮肤/软组织 (32.3%),骨髓炎 (19.4%) 和假肢关节感染 (16.1%).
- 所有的隔离物对素,诺基诺,里芬素和三甲胺-硫胺醇都敏感; 71%需要手术.
结论:
- 斯塔菲洛科克斯 (Staphylococcus caprae) 感染是一个新兴的问题,特别是在过去十年,其中很大一部分与牲畜接触有关.
- 皮肤和软组织感染是最常见的临床表现.
- 该病原体表现出对常见抗生素的持续敏感性,但持续监测对于管理这种动物传播威胁至关重要.
相关概念视频
01:30Toxidromes: Clinical Features
195
Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
195
01:25Endocarditis II: Clinical Features of Infective Endocarditis
950
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
950
01:29Staphylococcal Skin Infections
150
Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
150
01:14Atypical Pneumonia
88
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
88
01:25Mechanism of Antibiotic Resistance in MRSA
245
Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and...
245
01:25Clinical Significance of Antibiotic Resistance
106
Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
106