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感染相关的死产:对9年多学科研究的详细检查
Liliana Gabrielli1, Matteo Pavoni2, Francesca Monari3
1Microbiology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.
Microorganisms
|January 25, 2025
概括
感染是死产 (SB) 的轻微原因,在3.8%的病例中通过微生物学和组织学分析确定. 这项研究研究了母体,胎盘和胎儿组织,以了解感染和胎儿死亡之间的联系.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- 死产 (SB) 仍然是一个重大问题,其确切的原因往往未被确定.
- 人们还在讨论感染在死胎病因学中的作用.
- 需要一个多学科的方法来调查感染和胎儿死亡之间的潜在联系.
研究的目的:
- 调查感染和死产之间的因果关系.
- 为了分析母体,胎盘和胎儿组织的感染证据.
- 确定感染对发达国家死产的贡献.
主要方法:
- 在182例死产病例 (2014-2022) 的母体,胎盘和胎儿样本上进行微生物学调查 (血清学,培养,分子生物学).
- 标准化协议,包括强制性解剖和胎盘检查.
- 微生物学发现与器官损伤的组织学证据的相关性.
主要成果:
- 在各种样本中检测到细菌,包括胎盘活检 (65%) 和胎儿血液 (29%).
- 在阴道 (25.2%) 和口腔管 (8.6%) 抽样中发现了泌尿器官菌质.
- 六例病例显示细菌感染的微生物学和组织学证据;一个病例具有高SARS-CoV-2负载,与胎盘断裂相关.
结论:
- 在3.8%的死产病例中,感染被确定为胎儿死亡的可能原因.
- 感染被认为是发达国家死产的一个微不足道的因素,当被积极的微生物学和组织学定义时.
- 进一步的研究可能会澄清各种病原体在死胎病因学中的确切作用.
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